Potential Pharmacokinetics Interference Between -Glucosidase Inhibitors and Other Oral Antidiabetic Agents

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Potential pharmacokinetics interference between alpha-glucosidase inhibitors and other oral antidiabetic agents.

In the study recently reported by Chiasson et al. (1), it was concluded that miglitol, a pseudomonosaccharide α-glucosidase inhibitor, can be combined effectively with metformin therapy to give significantly greater reductions in HbAlc and postprandial plasma glucose levels than metformin alone in middle-aged patients in whom type 2 diabetes is insufficiently controlled by diet alone. The combi...

متن کامل

New inhibitors of glycogen phosphorylase as potential antidiabetic agents.

The protein glycogen phosphorylase has been linked to type 2 diabetes, indicating the importance of this target to human health. Hence, the search for potent and selective inhibitors of this enzyme, which may lead to antihyperglycaemic drugs, has received particular attention. Glycogen phosphorylase is a typical allosteric protein with five different ligand binding sites, thus offering multiple...

متن کامل

TEACHERS’ TOPICS Insulin and Oral Antidiabetic Agents

The current manuscript describes an overview for therapeutic approaches to treat diabetes mellitus. Detailed presentation of the role of insulin in both disease state development and therapy is given. The article also addresses the classification, chemistry, pharmacokinetic properties, dosage forms, mechanisms of action, and therapeutic indications of oral anti-diabetic agents currently availab...

متن کامل

Molecular Modeling Studies of Thiophenyl C-Aryl Glucoside SGLT2 Inhibitors as Potential Antidiabetic Agents

A QSAR study on thiophenyl derivatives as SGLT2 inhibitors as potential antidiabetic agents was performed with thirty-three compounds. Comparison of the obtained results indicated the superiority of the genetic algorithm over the simulated annealing and stepwise forward-backward variable method for feature selection. The best 2D QSAR model showed satisfactory statistical parameters for the data...

متن کامل

Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors

Diabetes is a metabolic disorder affecting about 220 million people worldwide. One of the most critical complications of diabetes is post-prandial hyper-glycemia (PPHG). Glucosidase inhibitor and α-amylase inhibitors are class of compounds that help in managing PPHG. Low-cost herbal treatment is recommended due to their lesser side effect for treatment of diabetes. Two plants with significant t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Diabetes Care

سال: 2002

ISSN: 0149-5992,1935-5548

DOI: 10.2337/diacare.25.1.247